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两个修改例子
修改之前: All together, table 1 showed that
LC/ESI/MSn procedure profiled more
than 80 phospholipid molecular species from both T. cuspidata
and T. chinensis var. mairei cells. Due to effects of
different molecular species on instrument response, the absolute
quantification of phospholipids has not been performed in our experiments.
The relative abundance of individual molecular species within a
phospholipids class was calculated according to Materials and Methods. As
shown in table 1, major molecular species composition of PC, PE, PS and PA
of T. cuspidata
at 2 weeks was similar to 2-week T. chinensis var.
mairei. For instance, 16:0/20:4 ( 18:1/18:3 and 18:2/18:2 ) , 16:0/20:3
and 18:2/20:4 PE were prevalent in PE species , which constituted 18.0
% , 13.8 % and 9.3 % of total PE
species in T. cuspidata, and 18.7 %, 13.3 %, 8.9 % in T. chinensis var.
mairei. PS molecular species profiles were much less complex than profiles
of PC and PE, and almost dominated by long-chain polyunsaturated
fatty acids ( PUFA ) 24:0/20:4 and 22:0/ 20:4 PS
in two Taxus
species cells. For PG and PI, the
most abundant molecular species were 16:0/18:3 and 16:0/18:2, which have
some differences in two Taxus species cells ( * P<0.05
). In
addition, special PUFA ( C20:4 or
C20:3 ) were relatively abundant in PE and PC species, including
16:0/20:4, 16:0/20:3, 18:2/20:4, 18:1/20:4 , 18:1/20:3 and 18:0/20:4. 修改之前: 3.5.
Applying to human plasma samples The blood from 10 clinical
patients was obtained and the plasma concentration of linomycin
determined with the proposed method and the results are shown as below
(Table 3). As is shown, linomycin was not
detected in most patients. These data suggest that the virtual absence of
absorption of this drug, which implies negligible passage into the general
circulation. However, this can not be confirmed in the absence of
information on the extent of metabolism.
